Recent advances in large-scale electrical and optical recording have made it possible to record and stimulate neural circuits at unprecedented scale and resolution [Jun et al., 2017, Kipke et al., 2008,

Abstract-- Foot drop is commonly managed using Functional Electrical Stimulation (FES), typically delivered via open-loop controllers with fixed stimulation intensities. While users may manually adjust the intensity through external controls, this approach risks overstimulation, leading to muscle fatigue and discomfort, or understimulation, which compromises dorsiflexion and increases fall risk. In this study, we propose a novel closed-loop FES controller that dynamically adjusts the stimulation intensity based on real-time toe clearance, providing "assistance as needed". We evaluate this system by inducing foot drop in healthy participants and comparing the effects of the closed-loop controller with a traditional open-loop controller across various walking conditions, including different speeds and surface inclinations. Kinematic data reveal that our closed-loop controller maintains adequate toe clearance without significantly affecting the joint angles of the hips, the knees, and the ankles, and while using significantly lower stimulation intensities compared to the open-loop controller . These findings suggest that the proposed method not only matches the effectiveness of existing systems but also offers the potential for reduced muscle fatigue and improved long-term user comfort and adherence.

Neural Information Processing Systems http://nips.cc/

Closed -loop brain stimulation holds potential as personalized treatment for drug-resistant epilepsy (DRE) but still suffers from limitations that result in highly variable efficacy. First, stimulation is typically delivered upon detection of the seizure to abort rather than prevent it; second, the stimulation parameters are established by trial and error, requiring lengthy rounds of fine -tuning, which delay steady-state therapeutic efficacy. Here, we address these limitations by leveraging the potential of neuromorphic computing. We present a neuromorphic reservoir computing hardware system capable of driving real - time personalized free-run stimulations based on seizure forecasting, wherein each forecast triggers an electrical pulse rather than an arbitrarily predefined fixed -frequency stimulus train. The system achieves 83.33% accuracy in forecasting seizure occurrences during the training phase. We validate the system using hippocampal spheroids coupled to 3D microelectrode array as a simplified testbed, achieving seizure reduction >97% during the real -time processing while primarily using instantaneous stimulation frequencies within 20 Hz, well below what typically used in clinical practice. Our work demonstrates the potential of neuromorphic systems as a next -generation neuromodulation strategy for personalized DRE treatment, leveraging their sparse and event-driven processing for real -time applications. Keywords: Neuromorphic system, drug-resistant epilepsy, seizure forecasting, neuromodulation, closed -loop stimulation, edge-devices.

We propose "Insect-Computer Hybrid Speaker", which enables us to make musics made from combinations of computer and insects. Lots of studies have proposed methods and interfaces for controlling insects and obtaining feedback. However, there have been less research on the use of insects for interaction with third parties. In this paper, we propose a method in which cicadas are used as speakers triggered by using Electrical Muscle Stimulation (EMS). We explored and investigated the suitable waveform of chirp to be controlled, the appropriate voltage range, and the maximum pitch at which cicadas can chirp.

In the pursuit of deeper immersion in human-machine interaction, achieving higher-dimensional tactile input and output on a single interface has become a key research focus. This study introduces the Visual-Electronic Tactile (VET) System, which builds upon vision-based tactile sensors (VBTS) and integrates electrical stimulation feedback to enable bidirectional tactile communication. We propose and implement a system framework that seamlessly integrates an electrical stimulation film with VBTS using a screen-printing preparation process, eliminating interference from traditional methods. While VBTS captures multi-dimensional input through visuotactile signals, electrical stimulation feedback directly stimulates neural pathways, preventing interference with visuotactile information. The potential of the VET system is demonstrated through experiments on finger electrical stimulation sensitivity zones, as well as applications in interactive gaming and robotic arm teleoperation. This system paves the way for new advancements in bidirectional tactile interaction and its broader applications.

The advancement of insect-computer hybrid robots holds significant promise for navigating complex terrains and enhancing robotics applications. This study introduced an automatic assembly method for insect-computer hybrid robots, which was accomplished by mounting backpack with precise implantation of custom-designed bipolar electrodes. We developed a stimulation protocol for the intersegmental membrane between pronotum and mesothorax of the Madagascar hissing cockroach, allowing for bipolar electrodes' automatic implantation using a robotic arm. The assembly process was integrated with a deep learning-based vision system to accurately identify the implantation site, and a dedicated structure to fix the insect (68 s for the whole assembly process). The automatically assembled hybrid robots demonstrated steering control (over 70 degrees for 0.4 s stimulation) and deceleration control (68.2% speed reduction for 0.4 s stimulation), matching the performance of manually assembled systems. Furthermore, a multi-agent system consisting of 4 hybrid robots successfully covered obstructed outdoor terrain (80.25% for 10 minutes 31 seconds), highlighting the feasibility of mass-producing these systems for practical applications. The proposed automatic assembly strategy reduced preparation time for the insect-computer hybrid robots while maintaining their precise control, laying a foundation for scalable production and deployment in real-world applications.

We present a new annotated microscopic cellular image dataset to improve the effectiveness of machine learning methods for cellular image analysis. Cell counting is an important step in cell analysis. Typically, domain experts manually count cells in a microscopic image. Automated cell counting can potentially eliminate this tedious, time-consuming process. However, a good, labeled dataset is required for training an accurate machine learning model. Our dataset includes microscopic images of cells, and for each image, the cell count and the location of individual cells. The data were collected as part of an ongoing study investigating the potential of electrical stimulation to modulate stem cell differentiation and possible applications for neural repair. Compared to existing publicly available datasets, our dataset has more images of cells stained with more variety of antibodies (protein components of immune responses against invaders) typically used for cell analysis. The experimental results on this dataset indicate that none of the five existing models under this study are able to achieve sufficiently accurate count to replace the manual methods. The dataset is available at https://figshare.com/articles/dataset/Dataset/21970604.

The centimeter-scale cyborg insects have a potential advantage for application in narrow environments where humans cannot operate. To realize such tasks, researchers have developed a small printed-circuit-board (PCB) which an insect can carry and control it. The electronic components usually remain bare on the board and the whole board is mounted on platform animals, resulting in uneven morphology of whole cyborg with sharp edges. It is well known that streamlined body shape in artificial vehicles or robots contributes to effective locomotion by reducing drag force in media. However, little is known how the entire body shape impacts on locomotor performance of cyborg insect. Here, we developed a 10 mm by 10 mm board which provided electrical stimulation via Sub-GHz communication and investigated the impact of physical arrangement of the board using Madagascar hissing cockroach. We compared the success rate of gap negotiation between the cyborg with mounted board and implanted board and found the latter outperformed the former. We demonstrated our cyborg cockroach with implanted board could follow faithfully to the locomotion command via antennal or cercal stimulation and traverse a narrow gap like air vent cover. In contrast to the conventional arrangement, our cyborg insects are suitable for application in a concealed environment.

The hybridisation of robot-assisted gait training and functional electrical stimulation (FES) can provide numerous physiological benefits to neurological patients. However, the design of an effective hybrid controller poses significant challenges. In this over-actuated system, it is extremely difficult to find the right balance between robotic assistance and FES that will provide personalised assistance, prevent muscle fatigue and encourage the patient's active participation in order to accelerate recovery. In this paper, we present an adaptive hybrid robot-FES controller to do this and enable the triadic collaboration between the patient, the robot and FES. A patient-driven controller is designed where the voluntary movement of the patient is prioritised and assistance is provided using FES and the robot in a hierarchical order depending on the patient's performance and their muscles' fitness. The performance of this hybrid adaptive controller is tested in simulation and on one healthy subject. Our results indicate an increase in tracking performance with lower overall assistance, and less muscle fatigue when the hybrid adaptive controller is used, compared to its non adaptive equivalent. This suggests that our hybrid adaptive controller may be able to adapt to the behaviour of the user to provide assistance as needed and prevent the early termination of physical therapy due to muscle fatigue.